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Science 16 November 1979:
Vol. 206. no. 4420, pp. 850 - 852
DOI: 10.1126/science.493987
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Articles

Science, Vol 206, Issue 4420, 850-852
Copyright © 1979 by American Association for the Advancement of Science

articles

Calcitonin: inhibitory effect on eating in rats

WJ Freed, MJ Perlow, and RJ Wyatt

Subcutaneous and intracerebral injections of calcitonin inhibited feeding in rats. The anorectic activity of calcitonin was destroyed by exposing the hormone to heat, trypsin, or hydrogen peroxide. Calcitonin did not produce a conditioned taste aversion to saccharin, and maximum inhibition of feeding occurred 4.5 to 8.3 hours after subcutaneous administration. It is concluded that calcitonin inhibits feeding by acting directly on the central nervous system.


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Interaction of calcitonin and calcitonin gene-related peptide at receptor sites in target tissues.
D Goltzman and J Mitchell (1985)
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Intraventricular calcitonin inhibits gastric acid secretion.
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Calcitonin messenger RNA encodes multiple polypeptides in a single precursor.
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Calcitonin: Aversive Effects in Rats?.
W. J. FREED, L. A. BING, and R. J. WYATT (1981)
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R. D. Reidelberger, L. Kelsey, and D. Heimann (2002)
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