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Science 2 November 1979:
Vol. 206. no. 4418, pp. 577 - 580
DOI: 10.1126/science.493963
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Articles

Science, Vol 206, Issue 4418, 577-580
Copyright © 1979 by American Association for the Advancement of Science

articles

Candidiasis: detection by gas-liquid chromatography of D-arabinitol, a fungal metabolite, in human serum

TE Kiehn, EM Bernard, JW Gold, and D Armstrong

D-Arabinitol was identified as a major metabolite of Candida species in human subjects. Gas-liquid chromatography was used to measure the concentration of D-arabinitol in serum. The study included subjects who were healthy and cancer patients who had proven invasive candidiasis or were colonized with Candida. D-Arabinitol concentrations greater than 1.0 microgram per milliliter were found in serum from patients with invasive infection. This technique may prove valuable in the diagnosis of invasive candidiasis.


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Current Status of Nonculture Methods for Diagnosis of Invasive Fungal Infections.
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Respiratory Alkalosis and Abdominal Pain Heralding Candida Hepatitis: Occurrence in Patients With Acute Leukemia in Remission.
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Disseminated Candidiasis: Newer Approaches to Early Recognition and Treatment.
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