Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 26 October 1979:
Vol. 206. no. 4417, pp. 481 - 483
DOI: 10.1126/science.228392
Prev | Table of Contents | Next

Articles

Science, Vol 206, Issue 4417, 481-483
Copyright © 1979 by American Association for the Advancement of Science

articles

Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia

TL Yaksh, DH Farb, SE Leeman, and TM Jessell

A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli.
D. J. Cavanaugh, H. Lee, L. Lo, S. D. Shields, M. J. Zylka, A. I. Basbaum, and D. J. Anderson (2009)
PNAS 106, 9075-9080
   Abstract »    Full Text »    PDF »
Use of a Fluorescent Imaging Plate Reader-Based Calcium Assay to Assess Pharmacological Differences between the Human and Rat Vanilloid Receptor.
D. G. Witte, S. C. Cassar, J. N. Masters, T. Esbenshade, and A. A. Hancock (2002)
J Biomol Screen 7, 466-475
   Abstract »    PDF »
An automated flinch detecting system for use in the formalin nociceptive bioassay.
T. L. Yaksh, G. Ozaki, D. McCumber, M. Rathbun, C. Svensson, S. Malkmus, and M. C. Yaksh (2001)
J Appl Physiol 90, 2386-2402
   Abstract »    Full Text »    PDF »
Vanilloid (Capsaicin) Receptors and Mechanisms.
A. Szallasi and P. M. Blumberg (1999)
Pharmacol. Rev. 51, 159-212
   Abstract »    Full Text »    PDF »
Chelation of Zinc in the Extracellular Area of the Spinal Cord, Using Ethylenediaminetetraacetic Acid Disodium-Calcium Salt or Dipicolinic Acid, Inhibits the Antinociceptive Effect of Capsaicin in Adult Mice.
A. A. Larson and K. F. Kitto (1999)
J. Pharmacol. Exp. Ther. 288, 759-765
   Abstract »    Full Text »
Rapid Communication: Salt-Sensitive Hypertension Induced by Sensory Denervation : Introduction of a New Model.
D. H. Wang, J. Li, and J. Qiu (1998)
Hypertension 32, 649-653
   Abstract »    Full Text »    PDF »
Pain and Analgesia: The Outlook for More Rational Treatment.
J. LEVINE (1984)
Ann Intern Med 100, 269-276
   Abstract »    PDF »
Regulation of Pain Sensitivity in the Central Nervous System.
K. Hole and O.-G. Berge (1981)
Cephalalgia 1, 51-59
   Abstract »    PDF »
Ligand-induced Dynamic Membrane Changes and Cell Deletion Conferred by Vanilloid Receptor 1.
Z. Olah, T. Szabo, L. Karai, C. Hough, R. D. Fields, R. M. Caudle, P. M. Blumberg, and M. J. Iadarola (2001)
J. Biol. Chem. 276, 11021-11030
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)