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Science 26 October 1979:
Vol. 206. no. 4417, pp. 471 - 473
DOI: 10.1126/science.504989
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Articles

Science, Vol 206, Issue 4417, 471-473
Copyright © 1979 by American Association for the Advancement of Science

articles

Cholecystokinin octapeptide: continuous picomole injections into the cerebral ventricles of sheep suppress feeding

MA Della-Fera and CA Baile

Cholecystokinin octapeptide decreased food intake in a dose-related manner when injected continuously into the lateral cerebral ventricles of sheep that had been deprived of food for 2, 4, 8, or 24 hours. In sheep deprived of food for 2 hours, as little as 0.01 picomole per minute suppressed feeding 35 percent 1 hour after beginning injection. Pentagastrin also decreased feeding in the 2-hour group, but only at a much higher dose range. Secretin had no effect. These findings support the hypothesis that cholecystokinin octapeptide acts on central nervous system structures that are involved in control of food intake.


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