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Science 19 October 1979:
Vol. 206. no. 4416, pp. 363 - 364
DOI: 10.1126/science.39341
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Articles

Science, Vol 206, Issue 4416, 363-364
Copyright © 1979 by American Association for the Advancement of Science

articles

Erythrosin B inhibition of neurotransmitter accumulation by rat brain homogenate

WJ Logan and JM Swanson

A mixture of seven food dyes inhibited the accumulation of eight neurotransmitters or neurotransmitter precursors by rat brain homogenate. At a low concentration (1 microgram per milliliter), erythrosin B (FD&C red 3) was the only dye that inhibited dopamine accumulation. Erythrosin also was effective in decreasing the accumulation of all the other transmitter substances, suggesting that the inhibition is nonspecific and probably secondary to general membrane alteration.


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Erythrosine (Red No. 3) and its nonspecific biochemical actions: what relation to behavioral changes?.
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