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Science 19 October 1979:
Vol. 206. no. 4416, pp. 344 - 347
DOI: 10.1126/science.482943
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Articles

Science, Vol 206, Issue 4416, 344-347
Copyright © 1979 by American Association for the Advancement of Science

articles

Synaptic regeneration in identified neurons of the lamprey spinal cords

MR Wood and MJ Cohen

Identified reticulospinal neurons whose giant axons were severed after spinal cord transection were filled with horseradish peroxidase. Whole mounts and serial-section light and electron micrographs show axon regeneration across the spinal lesion and the formation of new synapses. Normal swimming activity returns in the spinally transected animals, although the regenerated synapses are in atypical regions of the spinal cord.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Expression of the Netrin Receptor UNC-5 in Lamprey Brain: Modulation by Spinal Cord Transection.
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Neurorehabil Neural Repair 14, 49-58
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Recovery of Neurofilament Expression Selectively in Regenerating Reticulospinal Neurons.
A. J. Jacobs, G. P. Swain, J. A. Snedeker, D. S. Pijak, L. J. Gladstone, and M. E. Selzer (1997)
J. Neurosci. 17, 5206-5220
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Behavioral recovery induced by applied electric fields after spinal cord hemisection in guinea pig.
R. Borgens, A. Blight, and M. McGinnis (1987)
Science 238, 366-369
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Regeneration of functional synapses between individual recognizable neurons in the lamprey spinal cord.
S. Mackler and M. Selzer (1985)
Science 229, 774-776
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Promoting functional plasticity in the damaged nervous system.
W. Freed, L de Medinaceli, and R. Wyatt (1985)
Science 227, 1544-1552
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Directional specificity in the regeneration of lamprey spinal axons.
H. Yin, S. Mackler, and M. Selzer (1984)
Science 224, 894-896
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Extensive dendritic sprouting induced by close axotomy of central neurons in the lamprey.
G. Hall and M. Cohen (1983)
Science 222, 518-521
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Which behavior does the lamprey central motor program mediate?.
J Ayers, G. Carpenter, S Currie, and J Kinch (1983)
Science 221, 1312-1314
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Enhanced spinal cord regeneration in lamprey by applied electric fields.
R. Borgens, E Roederer, and M. Cohen (1981)
Science 213, 611-617
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