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Science 12 October 1979:
Vol. 206. no. 4415, pp. 225 - 227
DOI: 10.1126/science.225798
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Articles

Science, Vol 206, Issue 4415, 225-227
Copyright © 1979 by American Association for the Advancement of Science

articles

Calmodulin activation of adenylate cyclase in pancreatic islets

I Valverde, A Vandermeers, R Anjaneyulu, and WJ Malaisse

Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.


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Regulation of Inositol Trisphosphate Receptor Isoform Expression in Glucose-Desensitized Rat Pancreatic Islets: Role of Cyclic Adenosine 3',5'-Monophosphate and Calcium.
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Myosin light-chain phosphorylation controls insulin secretion at a proximal step in the secretory cascade.
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High Glucose Stimulates Early Response Gene c-Myc Expression in Rat Pancreatic beta Cells.
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