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Science 5 October 1979:
Vol. 206. no. 4414, pp. 75 - 76
DOI: 10.1126/science.482928
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Articles

Science, Vol 206, Issue 4414, 75-76
Copyright © 1979 by American Association for the Advancement of Science

articles

Shark heart mitochondria: effects of external osmolality on respiration

N Lewiston, A Newman, E Robin, and D Holtzman

Shark mitochondrial respiration was studied in media with osmolalities between 160 and 1500 milliosmoles. The respiratory control ratio, a marker for functional integrity of the isolated mitochondria, was maximal at 1000 millismoles and decreased during hypotonic or hypertonic exposure. Shark mitochondria function best at their native tonicity, a value that produces abnormal function in mammalian mitochondria.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)