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Science 28 September 1979:
Vol. 205. no. 4413, pp. 1418 - 1420
DOI: 10.1126/science.472761
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Articles

Science, Vol 205, Issue 4413, 1418-1420
Copyright © 1979 by American Association for the Advancement of Science

articles

Imbalance in X-chromosome expression: evidence for a human X-linked gene affecting growth of hemopoietic cells

L Luzzatto, EA Usanga, U Bienzle, GF Esan, and FA Fusuan

In each of six family members who were heterozygous at the X-linked locus for glucose-6-phosphate dehydrogenase, only one or the other of the two alleles at that locus was almost exclusively expressed. The data are consistent with evidence that X-chromosome inactivation is a random process that may be followed by selection for one of the two resulting cell types on the basis of an unknown gene, which is located on the X chromosome and which can affect the rate of proliferation of hemopoietic cells in humans.


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M. A. Vickers, E. McLeod, T. D. Spector, and I. J. Wilson (2001)
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X-linked genetic factors regulate hematopoietic stem-cell kinetics in females.
K. Christensen, M. Kristiansen, H. Hagen-Larsen, A. Skytthe, L. Bathum, B. Jeune, K. Andersen-Ranberg, J. W. Vaupel, and K. H. Orstavik (2000)
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Antiangiogenic Effects of Camptothecin Analogues 9-Amino-20(S)-camptothecin, Topotecan, and CPT-11 Studied in the Mouse Cornea Model.
J. J. O'Leary, R. L. Shapiro, C. J. Ren, N. Chuang, H. W. Cohen, and M. Potmesil (1999)
Clin. Cancer Res. 5, 181-187
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X-Linked Wiskott-Aldrich Syndrome in a Girl.
M. Cazzola, G. Bergamaschi, L. Luzzatto, G. Martini, O. Parolini, W. Knapp, and W. Holter (1998)
N. Engl. J. Med. 338, 1850-1851
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An X chromosome gene regulates hematopoietic stem cell kinetics.
J. L. Abkowitz, M. Taboada, G. H. Shelton, S. N. Catlin, P. Guttorp, and J. V. Kiklevich (1998)
PNAS 95, 3862-3866
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X-Chromosome inactivation in healthy females: incidence of excessive lyonization with age and comparison of assays involving DNA methylation and transcript polymorphisms.
N. El Kassar, G. Hetet, J. Briere, and B. Grandchamp (1998)
Clin. Chem. 44, 61-67
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