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Science 21 September 1979:
Vol. 205. no. 4412, pp. 1277 - 1279
DOI: 10.1126/science.472743
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Articles

Science, Vol 205, Issue 4412, 1277-1279
Copyright © 1979 by American Association for the Advancement of Science

articles

Acridine araphanes: a new class of probe molecules for biological systems

CM Himel, JL Taylor, C Pape, DB Millar, J Christopher, and L Kurlansik

The bis-acridine ring system forms the basis for new biophysical probes of novel stereochemistry. Spectral data indicate that certain alkylene bridged bis-9-aminoacridines have a parallel plane conformation of predictable interplane distance. The parallel plane conformation is independent of solvent and thus is different from nucleic acid systems. This stable conformation allows these compounds to be used as sensitive "rulers" for describing binding site geometry in cholinergic enzymes and in the delineation of the mechanism of allosteric control in acetylcholinesterase.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)