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Science 14 September 1979:
Vol. 205. no. 4411, pp. 1158 - 1161
DOI: 10.1126/science.472734
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Articles

Science, Vol 205, Issue 4411, 1158-1161
Copyright © 1979 by American Association for the Advancement of Science

articles

Regrowth of severed axons in the neonatal central nervous system: establishment of normal connections

K Kalil and T Reh

When pyramidal tract axons are cut in the adult hamster, fibers degenerate in both anterograde and retrograde directions from the lesion. If the same operation is performed on infant hamsters, however, there is massive regrowth of the severed axons via a new brainstem pathway to their appropriate terminal sites in the medulla and spinal cord. In contrast to previous studies, these results suggest that axons in the mammalian central nervous system damaged early in life may regenerate in a functionally useful way.


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