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Science 14 September 1979:
Vol. 205. no. 4411, pp. 1147 - 1149
DOI: 10.1126/science.224459
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Articles

Science, Vol 205, Issue 4411, 1147-1149
Copyright © 1979 by American Association for the Advancement of Science

articles

[3H]GABA binding in brains from Huntington's chorea patients: altered regulation by phospholipids?

KG Lloyd and L Davidson

Binding sites for tritum-labeled gamma-aminobutyric acid (GABA) in cerebellar cortex of Huntington's chorea patients have an increased affinity but unaltered maximum capacity as compared to binding sites in tissue from control patients. A similar binding pattern is produced in control membranes by treatment with Triton X-100, phospholipase C, or glycerophosphoethanolamine. Thus, it is likely that phospholipids or their metabolites regulate the accessibility of the GABA binding site and that this regulation is abnormal in Huntington's chorea.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)