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Science 17 August 1979:
Vol. 205. no. 4407, pp. 693 - 696
DOI: 10.1126/science.223243
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Articles

Science, Vol 205, Issue 4407, 693-696
Copyright © 1979 by American Association for the Advancement of Science

articles

Cerebral cortical microfluorometry at isosbestic wavelengths for correction of vascular artifact

RS Kramer and RD Pearlstein

Microfluorometric measurements of cerebral cortical mitochondrial respiration in vivo are obscured by hemodynamic and oximetric artifacts. Isosbestic fluorometry provides appropriate correction for these vascular phenomena and permits simultaneous evaluation of mitochondrial nicotinamide adenine dinucleotide redox state, microcirculatory volume, and hemoglobin oxygenation.


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