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Science 3 August 1979:
Vol. 205. no. 4405, pp. 499 - 501
DOI: 10.1126/science.377493
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Articles

Science, Vol 205, Issue 4405, 499-501
Copyright © 1979 by American Association for the Advancement of Science

articles

Heparin neutralization of PGI2: effects upon platelets

HI Saba, Saba SR, CA Blackburn, RC Hartmann, and RG Mason

Heparin neutralizes the inhibitory effect of prostacyclin (PGI2) on platelet aggregation. The PGI2-induced enhancement of platelet cyclic adenosine monophosphate levels is also inhibited. The mechanism appears to involve a direct interaction in which heparin neutralizes the inhibitory effects of PGI2 on platelet aggregation but, at the same time, does not lose its own anticoagulant activity. These findings may explain instances in which heparin infusions have been reported to produce hyperaggregation of platelets, thrombotic episodes, and thrombocytopenia in patients.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Effects of Intracellular and Extracellular Calcium Blockers on the Pulmonary Vascular Responses to PGF2{alpha} and U46619.
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Angiology 38, 51-55
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Stroke: The Use and Overuse of Heparin in Therapeutic Trials.
J. I. Sage (1985)
Arch Neurol 42, 315-317
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Heparin-Associated Thrombocytopenia.
D. J. KING and J. G. KELTON (1984)
Ann Intern Med 100, 535-540
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