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Science 27 July 1979:
Vol. 205. no. 4404, pp. 407 - 408
DOI: 10.1126/science.313077
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Articles

Science, Vol 205, Issue 4404, 407-408
Copyright © 1979 by American Association for the Advancement of Science

articles

Preferential transmission of the Z deficient allele of alpha 1-antitrypsin

C Chapuis-Cellier and P Arnaud

The transmission of the Z deficient allele of alpha 1-antitrypsin was studied in 23 families, each with a single parent heterozygous for this allele. When the mother carried the Z allele, the distribution of phenotypes in the children did not differ significantly from the expected frequency. In contrast, when the father was the carrier, a significant increase of heterozygous phenotypes was observed in the children. This observation suggests that a selective advantage is associated with the expression of the Z allele in male gametes.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)