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Science 20 July 1979:
Vol. 205. no. 4403, pp. 313 - 316
DOI: 10.1126/science.451605
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Articles

Science, Vol 205, Issue 4403, 313-316
Copyright © 1979 by American Association for the Advancement of Science

articles

Noradrenergic innervation of cerebral cortex: widespread effects of local cortical lesions

JH Morrison, ME Molliver, and R Grzanna

The trajectory of the intracortical noradrenergic fibers has been characterized by histochemical analysis following the production of cortical lesions in the rate. A large group of noradrenergic fibers enters the cortex at the frontal pole and proceeds caudally through the deep layers of dorsolateral cortex. Branches arise from these longitudinally directed fibers and form a uniform pattern of innervation throughout lateral cortex. Because these fibers travel long distances rostrocaudally within the gray matter, a large area of cortex can be deprived of noradrenergic innervation by a relatively small lesion of frontal cortex. The medial and lateral cortex can be selectively and differentially denervated of noradrenergic fibers, and there is a medial to lateral topographic relationship between deep longitudinally running fibers and overlying cortex.


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