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Science 13 July 1979:
Vol. 205. no. 4402, pp. 209 - 211
DOI: 10.1126/science.451592
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Articles

Science, Vol 205, Issue 4402, 209-211
Copyright © 1979 by American Association for the Advancement of Science

articles

Medial septal lesions retard classical conditioning of the nicitating membrane response in rabbits

SD Berry and RF Thompson

Lesions of the medial septum were produced in 7 of 14 rabbits prior to classical conditioning of the nictitating membrane response. Lesions significantly altered the hippocampal electroencephalogram, attenuated conditioned hippocampal unit responses, and slowed the behavioral rate of acquisition. The contrast of the behavioral results with those of studies of massive septal or hippocampal ablation suggests a functional subdivision of the septo-hippocampal system in learning.


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