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Science 13 July 1979:
Vol. 205. no. 4402, pp. 200 - 202
DOI: 10.1126/science.451590
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Articles

Science, Vol 205, Issue 4402, 200-202
Copyright © 1979 by American Association for the Advancement of Science

articles

Erythrocytes: a new cell type for the evaluation of insulin receptor defects in diabetic humans

TJ Robinson, JA Archer, KK Gambhir, VW Hollis Jr, L Carter, and C Bradley

Human erythrocytes have specific insulin receptors. When studied in an insulin radioreceptor assay, erythrocytes from adult-onset, nonobese diabetic subjects bound at least 42 percent less insulin than the normal subjects at insulin concentrations from 0.1 to 100 nanograms per milliliter. The diabetic subjects had 190 insulin receptor sites per cell as compared with the 380 insulin receptor sites per cell for the normal subjects. The deficit of insulin binding in the diabetic subject was thus associated with a fewer number of insulin binding sites per cell with little or no change in affinity. The erythrocyte is a readily available cell for the evaluation of cellular insulin receptor activity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Coordinated Regulation of Insulin Signaling by the Protein Tyrosine Phosphatases PTP1B and TCPTP.
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Sequential phosphorylation of protein band 3 by Syk and Lyn tyrosine kinases in intact human erythrocytes: identification of primary and secondary phosphorylation sites.
A. M. Brunati, L. Bordin, G. Clari, P. James, M. Quadroni, E. Baritono, L. A. Pinna, and A. Donella-Deana (2000)
Blood 96, 1550-1557
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Attogram detection limit for aqueous dye samples by laser-induced fluorescence.
N. Dovichi, J. Martin, J. Jett, and R. Keller (1983)
Science 219, 845-847
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