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Science 22 June 1979:
Vol. 204. no. 4399, pp. 1343 - 1344
DOI: 10.1126/science.221973
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Articles

Science, Vol 204, Issue 4399, 1343-1344
Copyright © 1979 by American Association for the Advancement of Science

articles

ACTH and vasopressin treatments immediately after a defeat increase future submissiveness in male mice

KE Roche and AI Leshner

Male mice were given a single injection of either adrenocorticotropic hormone (ACTH) or lysine vasopressin immediately after a defeat in an encounter with an aggressive male mouse. The defeated mice were tested for submissiveness at either 24 hours, 48 hours, or 7 days after the initial encounter. Both hormone treatments increased future submissiveness, although the time courses of the effects were different: The effects of ACTH disappeared after 48 hours, whereas those of vasopressin persisted for 7 days. These results suggest that changes in peptide hormone levels following naturally stressful experiences can affect the memory of those experiences, as expressed in future adaptive responses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Opioid-like analgesia in defeated mice.
K. Miczek, M. Thompson, and L Shuster (1982)
Science 215, 1520-1522
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