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Science 15 June 1979:
Vol. 204. no. 4398, pp. 1233 - 1235
DOI: 10.1126/science.221979
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Articles

Science, Vol 204, Issue 4398, 1233-1235
Copyright © 1979 by American Association for the Advancement of Science

articles

Norepinephrine inhibits calcium-dependent potentials in rat sympathetic neurons

JP Horn and DA McAfee

Norepinephrine reversibly antagonizes three calcium-dependent potentials recorded from rat postganglionic neurons. Norepinephrine inhibits the development of a shoulder on the aciton potential, the magnitude of the hyperpolarizing afterpotential, and the rate of rise and amplitude of the calcium spike. The action of norepinephrine is antagonized by the alpha-adrenergic antagonist phentolamine, but not by MJ 1999, a beta-adrenergic antagonist. These results suggest that activation of an alpha-adrenergic receptor may antagonize a voltage-sensitive calcium current.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential Inhibition of Ca2+ Channels by {alpha}2-Adrenoceptors in Three Functional Subclasses of Rat Sympathetic Neurons.
C. Li and J. P. Horn (2008)
J Neurophysiol 100, 3055-3063
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