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Science 8 June 1979:
Vol. 204. no. 4397, pp. 1096 - 1098
DOI: 10.1126/science.36660
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Articles

Science, Vol 204, Issue 4397, 1096-1098
Copyright © 1979 by American Association for the Advancement of Science

articles

Neuronal supersensitivity to acetylcholine induced by kindling in the rat hippocampus

JL Burchfiel, MS Duchowny, and FH Duffy

Kindling is an experimental model of epilepsy in which periodic brain stimulation induces the progressive development of electrical and behavioral seizures. A kindling-induced electrical seizure (afterdischarge) in the rat hippocampus produces prolonged neuronal supersensitivity to microiontophoretically applied acetylcholine after a latency of 40 to 60 minutes. Neuronal acetylcholine supersensitivity is correlated with the further progression of kindling. A larger hippocampal after-discharge is elicited by a subsequent kindling stimulus delivered in the presence of acetylcholine supersensitivity, but not by one delivered before the onset of the supersensitivity. The results suggest that alteration of synaptic sensitivity to acetylcholine may contribute to kindling and epileptogenesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of Kindling Epileptogenesis by Hippocampal Galanin Type 1 and Type 2 Receptors: The Effects of Subtype-Selective Agonists and the Role of G-Protein-Mediated Signaling.
A. Mazarati, L. Lundstrom, U. Sollenberg, D. Shin, U. Langel, and R. Sankar (2006)
J. Pharmacol. Exp. Ther. 318, 700-708
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