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Science 11 May 1979:
Vol. 204. no. 4393, pp. 624 - 626
DOI: 10.1126/science.432666
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Articles

Science, Vol 204, Issue 4393, 624-626
Copyright © 1979 by American Association for the Advancement of Science

articles

Hydroxylase cofactor activity in cerebrospinal fluid of normal subjects and patients with Parkinson's disease

W Lovenberg, RA Levine, DS Robinson, M Ebert, AC Williams, and DB Calne

A method for measuring hydroxylase cofactor activity in human cerebrospinal fluid is described. The hydroxylase cofactor content of cerebrsopinal fluid from Parkinsonian patients is approximately 50 percent that of normal subjects. A significant correlation between hydroxylase cofactor and the concentration of homovanillic acid in the cerebrospinal fluid was observed.


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