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Science 20 April 1979:
Vol. 204. no. 4390, pp. 312 - 313
DOI: 10.1126/science.107588
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Articles

Science, Vol 204, Issue 4390, 312-313
Copyright © 1979 by American Association for the Advancement of Science

articles

Prolongation of islet allograft survival following in vitro culture (24 degrees C) and a single injection of ALS

PE Lacy, JM Davie, and EH Finke

Isolated rat islets remain morphologically and functionally intact during a 7-day period of in vitro culture at 24 degrees C. In vitro culture of islets at 24 degrees C for 7 days prior to transplantation, in conjunction with a single injection of antiserum to lymphocytes into the diabetic recipient, results in islet allograft survival of 100 days when the islets are transplanted across a major histocompatibility barrier.


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