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Science 13 April 1979:
Vol. 204. no. 4389, pp. 203 - 205
DOI: 10.1126/science.432642
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Articles

Science, Vol 204, Issue 4389, 203-205
Copyright © 1979 by American Association for the Advancement of Science

articles

Induction of copulatory behavior in sexually inactive rats by naloxine

GL Gessa, E Paglietti, and BP Quarantotti

The intraventricular injection of D-alanine-methionine-enkephalinamide (D-Ala2-Met-enkephalinamide), a synthetic analog of Met-enkephalin that is resistant to enzymatic degradation, inhibits copulatory behavior in sexually vigorous male rats in doses which do not influence motor activity or feeding behavior. This effect is prevented by naloxone, a specific inhibitor of opioid receptors. In addition, injections of naloxone induce copulatory behavior in sexually inactive male rats. These results suggest that endorphins play an important role in the regulation of sexual behavior.


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