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Science 6 April 1979:
Vol. 204. no. 4388, pp. 79 - 80
DOI: 10.1126/science.86207
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Articles

Science, Vol 204, Issue 4388, 79-80
Copyright © 1979 by American Association for the Advancement of Science

articles

Simultaneous production of Q and R bands after staining with chromomycin A3 or olivomycin

G Prantera, S Bonaccorsi, and S Pimpinelli

Human and mouse chromosomes, stained with either chromomycin A3 or olivomycin, which bind preferentially to G - C-rich DNA (where G is guanosine and C is cytosine), exhibit a Q or a reverse banding pattern, depending on the wavelength used for excitation. The two complementary banding patterns can be observed in the same metaphase simply by changing the combination of excitation filters. These data suggest, therefore, that in addition to base composition, other factors are involved in the production of chromosome banding by chromomycin A3 and olivomycin.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)