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Science 30 March 1979:
Vol. 203. no. 4387, pp. 1348 - 1349
DOI: 10.1126/science.284587
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Articles

Science, Vol 203, Issue 4387, 1348-1349
Copyright © 1979 by American Association for the Advancement of Science

articles

Control of oscillations in hematopoiesis

ND Kazarinoff and P van denDriessche

Results of a mathematical analysis of models of hematopoietic systems introduced by Mackey and Glass are given. The models include a constant time lag, and it is shown that this lag has a critical value above which oscillations in blood cell concentration occur. To reduce the likelihood of disease associated with such oscillations, physiologists should seek to learn how to increase this critical value of the lag.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cyclical Neutropenia and Other Periodic Hematological Disorders: A Review of Mechanisms and Mathematical Models.
C. Haurie, D. C. Dale, and M. C. Mackey (1998)
Blood 92, 2629-2640
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Science. ISSN 0036-8075 (print), 1095-9203 (online)