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Science 16 March 1979:
Vol. 203. no. 4385, pp. 1129 - 1131
DOI: 10.1126/science.424743
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Articles

Science, Vol 203, Issue 4385, 1129-1131
Copyright © 1979 by American Association for the Advancement of Science

articles

Opioid peptides modulate luteinizing hormone secretion during sexual maturation

MS Blank, AE Panerai, and HG Friesen

Subcutaneous injections of naloxone, an opiate antagonist, lead to an increase in serum luteinizing hormone concentrations in female but not in male rats before they reach puberty. In addition, estradiol benzoate specifically blocks the luteinizing hormone response to naloxone in prepubertal female rats, suggesting that the opioid peptides have a physiological role in the endocrine events leading to sexual maturation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Minireview: The Neuroendocrine Regulation of Puberty: Is the Time Ripe for a Systems Biology Approach?.
S. R. Ojeda, A. Lomniczi, C. Mastronardi, S. Heger, C. Roth, A.-S. Parent, V. Matagne, and A. E. Mungenast (2006)
Endocrinology 147, 1166-1174
   Abstract »    Full Text »    PDF »
In Pubertal Girls, Naloxone Fails to Reverse the Suppression of Luteinizing Hormone Secretion by Estradiol.
A. P. Cemeroglu, G. B. Kletter, W. Guo, M. B. Brown, R. P. Kelch, J. C. Marshall, V. Padmanabhan, and C. M. Foster (1998)
J. Clin. Endocrinol. Metab. 83, 3501-3506
   Abstract »    Full Text »
Acute Effects of Estradiol Infusion and Naloxone on Luteinizing Hormone Secretion in Pubertal Boys.
G.B. Kletter, V. Padmanabhan, I.Z. Beitins, J.C. Marshall, R.P. Kelch, and C.M. Foster (1997)
J. Clin. Endocrinol. Metab. 82, 4010-4014
   Abstract »    Full Text »    PDF »
Metkephamid, a systemically active analog of methionine enkephalin with potent opioid alpha-receptor activity.
R. Frederickson, E. Smithwick, R Shuman, and K. Bemis (1981)
Science 211, 603-605
   Abstract »    PDF »


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