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Science 16 February 1979:
Vol. 203. no. 4381, pp. 668 - 670
DOI: 10.1126/science.760213
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Articles

Science, Vol 203, Issue 4381, 668-670
Copyright © 1979 by American Association for the Advancement of Science

articles

Human muscular dystrophy: elevation of urinary dimethylarginines

MF Lou

The amounts of the dimethylarginines NG,NG-dimethylarginine (DMA) and NG,N'G-dimethylarginine (DM'A) excreted in the urine of muscular dystrophic patients were examined and compared with the amounts excreted by normal controls, patients with other types of neuromuscular diseases, and patients with disuse muscle atrophy resulting from traumatic paralysis. The patients with muscular dystrophy excreted high concentrations of DMA and this urine showed high ratios of DMA to DM'A. This finding indicates a relation between protein methylation processes and muscular dystrophy.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Stimulation of Endogenous Nitric Oxide Pathway by L-Arginine Reduces Declamp Mortality and Attenuates Hypertension Associated With Aortic Cross-Clamp–Induced Hindlimb Ischemia in Rats.
J.-S. Jin and L. G. D'Alecy (1995)
Hypertension 26, 406-412
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