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Science 26 January 1979:
Vol. 203. no. 4378, pp. 369 - 371
DOI: 10.1126/science.32620
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Articles

Science, Vol 203, Issue 4378, 369-371
Copyright © 1979 by American Association for the Advancement of Science

articles

Methylazoxymethanol treatment of fetal rats results in abnormally dense noradrenergic innervation of neocortex

MV Johnston, R Grzanna, and JT Coyle

A single injection of methylazoxymethanol in pregnant rats at 15 days of gestation results in severe cortical atrophy in the offspring. In the adult offspring, the neurochemical markers for the cortical gamma-aminobutyric acid-containing neurons are severely reduced, whereas the noradrenergic markers are minimally altered. Immunohistofluorescence microscopy demonstrates a marked increase in the density of noradrenergic axons which have an abnormal pattern of distribution in the atrophic cortex. The results suggest that the central noradrenergic neurons determine the number of axons to be formed early in brain development, but local factors in the terminal field regulate the ultimate distribution of the noradrenergic axons.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hippocampal Heterotopia Lack Functional Kv4.2 Potassium Channels in the Methylazoxymethanol Model of Cortical Malformations and Epilepsy.
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Interference with the Development of Early Generated Neocortex Results in Disruption of Radial Glia and Abnormal Formation of Neocortical Layers.
S. C. Noctor, S. L. Palmer, T. Hasling, and S. L. Juliano (1999)
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Dopamine Metabolism in the Cerebrospinal Fluid of Drug-Free Schizophrenic Patients With and Without Cortical Atrophy.
D. P. van Kammen, W. B. van Kammen, L. S. Mann, T. Seppala, and M. Linnoila (1986)
Arch Gen Psychiatry 43, 978-983
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Alzheimer's disease: a disorder of cortical cholinergic innervation.
J. Coyle, D. Price, and M. DeLong (1983)
Science 219, 1184-1190
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