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Science 26 January 1979:
Vol. 203. no. 4378, pp. 365 - 367
DOI: 10.1126/science.216075
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Articles

Science, Vol 203, Issue 4378, 365-367
Copyright © 1979 by American Association for the Advancement of Science

articles

Lithium: a modulator of cyclic AMP-dependent events in lymphocytes?

EW Gelfand, HM Dosch, B Hastings, and A Shore

Theophylline, salbutamol, isoproterenol, and dibutyryl cyclic AMP inhibited E-rosette formation by human T lymphocytes and immunoglobulin M secretion from human plaque-forming B cells and augmented T-suppressor cell activity in three patients with agammaglobulinemia. Lithium chloride increased mitogen-induced lymphocyte proliferation and inhibited suppressor cell activity. In the presence of lithium, the effects of all the drugs except dibutyryl cyclic AMP could be prevented. The data suggest a role for lithium in the modulation of cyclic AMP-dependent events in lymphocytes. Its potential role as an inhibitor of suppressor cell activity warrants further attention.


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