Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 5 January 1979:
Vol. 203. no. 4375, pp. 68 - 69
DOI: 10.1126/science.758680
Prev | Table of Contents | Next

Articles

Science, Vol 203, Issue 4375, 68-69
Copyright © 1979 by American Association for the Advancement of Science

articles

Cholecystokinin in the brains of obese and nonobese mice

E Straus and RS Yalow

Extracts of the cerebral cortes of genetically obese (ob/ob) mice with hyperphagia contain 0.05 +/- 0.02 microgram (mean +/- standard error) of cholecystokinin octapeptide equivalent per gram of wet weight compared to 0.15 +/- 0.01 microgram per gram for their nonobese littermates and 0.20 +/- 0.01 microgram per gram for normal LAF1 mice. These findings are suggestive of a causal relation between the diminished brain immunoreactive cholecystokinin content and the unrestrained appetite of the obese mice.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia.
P. Faris, B. Komisaruk, L. Watkins, and D. Mayer (1983)
Science 219, 310-312
   Abstract »    PDF »
Cholecystokinin antibody injected in cerebral ventricles stimulates feeding in sheep.
M. Della-Fera, C. Baile, B. Schneider, and J. Grinker (1981)
Science 212, 687-689
   Abstract »    PDF »
Cholecystokinin receptors in the brain: characterization and distribution.
A Saito, H Sankaran, I. Goldfine, and J. Williams (1980)
Science 208, 1155-1156
   Abstract »    PDF »
Cholecystokinin octapeptide: continuous picomole injections into the cerebral ventricles of sheep suppress feeding.
M. Della-Fera and C. Baile (1979)
Science 206, 471-473
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)