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Science 22 December 1978:
Vol. 202. no. 4374, pp. 1290 - 1293
DOI: 10.1126/science.364652
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Articles

Science, Vol 202, Issue 4374, 1290-1293
Copyright © 1978 by American Association for the Advancement of Science

articles

Design of liposomes for enhanced local release of drugs by hyperthermia

MB Yatvin, JN Weinstein, WH Dennis, and R Blumenthal

Liposomes can be designed to release an entrapped drug preferentially at temperatures attainable by mild local hyperthermia. In a test system in vitro, protein synthesis by Escherichia coli is inhibited and killing of the cells is enhanced by heating neomycin-containing liposomes to their phase transition temperature to maximize drug release. In the presence of serum the ratio of release at 44 degrees C to that at 37 degrees C can be made greater than 100:1, suggesting possible applications in the treatment of tumors or local infection.


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