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Science 8 December 1978:
Vol. 202. no. 4372, pp. 1091 - 1093
DOI: 10.1126/science.152460
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Articles

Science, Vol 202, Issue 4372, 1091-1093
Copyright © 1978 by American Association for the Advancement of Science

articles

Angiotensin regulates release and synthesis of serotonin in brain

VE Nahmod, S Finkielman, EE Benarroch, and CJ Pirola

Angiotensin II released serotonin from neuron terminals and accelerated synthesis of the serotonin. This increase in synthesis depended on the activation of tryptophan hydroxylase. A biphasic effect was observed: at high doses the stimulatory effect depended on conversion of angiotensin II to angiotensin III. At low doses an inhibitory effect was found, possible dependent on an angiotensin II metabolite. These actions represent a subtle regulation of the open-loop serotonin system.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)