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Science 17 November 1978:
Vol. 202. no. 4369, pp. 775 - 778
DOI: 10.1126/science.715443
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Articles

Science, Vol 202, Issue 4369, 775-778
Copyright © 1978 by American Association for the Advancement of Science

articles

Decrease in adrenergic axon sprouting in the senescent rat

SW Scheff, LS Bernardo, and CW Cotman

When the septal area in young adult rats is denervated by a lesion of the fimbria-fornix, adrenergic fibers proliferate within the denervated area. The same operation performed on aged animals gives rise to a qualitatively similar but quantitatively less pronounced response. This reduction in reactive growth may reflect a decreased capacity of the aged brain to remodel its circuitry and restore lost function.


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Delayed and Blunted Induction of mRNA for Tissue Plasminogen Activator in the Brain of Old Rats Following Pentylenetetrazole-Induced Seizure Activity.
A. Popa-Wagner, B. Fischer, D. Platt, H. Schmoll, and C. Kessler (2000)
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