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Science 17 November 1978:
Vol. 202. no. 4369, pp. 765 - 768
DOI: 10.1126/science.213832
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Articles

Science, Vol 202, Issue 4369, 765-768
Copyright © 1978 by American Association for the Advancement of Science

articles

Cellular interactions uncouple beta-adrenergic receptors from adenylate cyclase

G Ciment and J de Vellis

C6 glioma cells and B104 neuroblastoma cells both possess adenylate cyclase activity, but only C6 cells have beta-adrenergic receptors. However, when cocultured with B104 cells, C6 cells show a marked decrease in their ability to accumulate adenosine 3', 5'-monophosphate upon stimulation with beta receptor agonists. Since both beta receptors and cholera toxin-stimulated adenylate cyclase activities are present in C6/B104 cocultures, we conclude that the beta receptor/adenylate cyclase transduction mechanism in cocultured C6 cells is uncoupled.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter.
L. Yotti, C. Chang, and J. Trosko (1979)
Science 206, 1089-1091
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