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Science 10 November 1978:
Vol. 202. no. 4368, pp. 633 - 635
DOI: 10.1126/science.81524
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Articles

Science, Vol 202, Issue 4368, 633-635
Copyright © 1978 by American Association for the Advancement of Science

articles

Slow axonal transport of neurofilament proteins: impairment of beta,beta'-iminodipropionitrile administration

JW Griffin, PN Hoffman, AW Clark, PT Carroll, and DL Price

beta,beta'-Iminodipropionitrile (IDPN) administration prevented normal slow axonal transport of [35S]methionine- or [3H]leucine-labeled proteins in rat sciatic motor axons. Ultrastructural and electrophoretic studies showed that the neurofilament triplet proteins in particular were retained within the initial 5 millimeters of the axons, resulting in neurofilament-filled axonal swellings. Fast anterograde and retrograde axonal transport were not affected. The IDPN thus selectively impaired slow axonal transport. The neurofibrillary pathology in this model is the result of the defective slow transport of neurofilaments.


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