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Science 3 November 1978:
Vol. 202. no. 4367, pp. 526 - 528
DOI: 10.1126/science.568310
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Articles

Science, Vol 202, Issue 4367, 526-528
Copyright © 1978 by American Association for the Advancement of Science

articles

Phagocytosis of light- and dark-adapted rod outer segments by cultured pigment epithelium

MO Hall

Pigment epithelial cells in culture retain their ability to phagocytize rod outer segments. These cells phagocytize rod outer segments isolated from light-adapted rats, or from dark-adapted rats killed after the time at which the lights would normally be turned on. However, they phagocytize for fewer rod outer segments prepared in the dark from the retinas of rats killed before the onset of the normal light cycle. Phagocytosis of dark rod outer segments is variable, but that of light outer segments is reproducible. It is postulated that the effect of light is to synchronize the chemical events that occur at the surface of the rods to prepare them for phagocytosis. These processes also occur in the dark, but more slowly and irregularly than in the light.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of Intracellular Phospholipases A2 in the Human Eye: Involvement in Phagocytosis of Photoreceptor Outer Segments.
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Basement Membrane-Dependent Modification of Phenotype and Gene Expression in Human Retinal Pigment Epithelial ARPE-19 Cells.
P. Turowski, P. Adamson, J. Sathia, J. J. Zhang, S. E. Moss, G. W. Aylward, M. J. Hayes, N. Kanuga, and J. Greenwood (2004)
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Oxidized Low Density Lipoprotein-Induced Inhibition of Processing of Photoreceptor Outer Segments by RPE.
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Immunophagocytic properties of retinal pigment epithelium cells.
V. Elner, T Schaffner, K Taylor, and S Glagov (1981)
Science 211, 74-76
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