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Science 3 November 1978:
Vol. 202. no. 4367, pp. 515 - 519
DOI: 10.1126/science.705341
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Articles

Science, Vol 202, Issue 4367, 515-519
Copyright © 1978 by American Association for the Advancement of Science

articles

Atmospheric reactions of polycyclic aromatic hydrocarbons: facile formation of mutagenic nitro derivatives

JN Pitts Jr, KA Van Cauwenberghe, D Grosjean, JP Schmid, DR Fitz, WL Belser, GP Knudson, and PM Hynds

Directly active mutagens are formed on exposure of the promutagen benzo[a]pyrene to gaseous pollutants in smog. In simulated atmospheres containing 1 part per million nitrogen dioxide and traces of nitric acid, directly mutagenic nitro derivatives are readily formed from both benzo[a]pyrene and perylene, a non-mutagen in the Ames reversion assay. Possible formation of direct mutagens by such reactions on sample collection filters, in exhaust effluents, and in the atmosphere should be recognized.


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