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Science 13 October 1978:
Vol. 202. no. 4364, pp. 227 - 228
DOI: 10.1126/science.694530
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Articles

Science, Vol 202, Issue 4364, 227-228
Copyright © 1978 by American Association for the Advancement of Science

articles

Cocaine plasma concentration: relation to physiological and subjective effects in humans

JI Javaid, MW Fischman, CR Schuster, H Dekirmenjian, and JM Davis

Volunteer subjects with previous histories of cocaine use were administered cocaine hydrochloride intravenously or intranasally. There was a positive relationship between peak plasma concentration, physiological and subjective responses, and dose administered. The rate of cocaine disappearance after intravenous administration paralleled the drop in physiological and subjective drug effects. After intranasal administration, blood levels remained elevated for a considerably longer period.


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Time of Onset of Necrotizing Enterocolitis in Newborn Infants with Known Prenatal Cocaine Exposure.
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Recurrent Coronary Vasoconstriction Caused by Intranasal Cocaine: Possible Role for Metabolites.
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Myocardial Ischemia during Cocaine Withdrawal.
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Ann Intern Med 111, 876-880
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Suspiciousness Induced by Four-Hour Intravenous Infusions of Cocaine: Preliminary Findings.
M. A. Sherer, K. M. Kumor, E. J. Cone, and J. H. Jaffe (1988)
Arch Gen Psychiatry 45, 673-677
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Cocaine receptors on dopamine transporters are related to self-administration of cocaine.
M. Ritz, R. Lamb, Goldberg SR, and M. Kuhar (1987)
Science 237, 1219-1223
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