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Science 6 October 1978:
Vol. 202. no. 4363, pp. 66 - 68
DOI: 10.1126/science.308697
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Articles

Science, Vol 202, Issue 4363, 66-68
Copyright © 1978 by American Association for the Advancement of Science

articles

Impulse blockade in frog cardiac ganglion does not resemble partial denervation in changing synaptic organization

S Roper and CP Ko

Partial denervation of parasympathetic neurons in the frog heart by surgical section of one vagus nerve results in a marked reorganization of functional synaptic connections made by the remaining vagus nerve. These changes are not simply due to a lack of impulse activity per se in the sectioned nerve because blockage of impulses in one vagus with tetrodotoxin-impregnated cuffs did not cause similar changes in the innervation pattern of the ganglion. Furthermore, tetrodotoxin-blocked vagal fibers retain their ability to sprout and can form new synapses on denervated neurons.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Postsynaptic transmission block can cause terminal sprouting of a motor nerve.
R. Holland and M. Brown (1980)
Science 207, 649-651
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