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Science 6 October 1978: Vol. 202. no. 4363, pp. 56 - 58 DOI: 10.1126/science.694518
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Articles
Science, Vol 202, Issue 4363, 56-58
Copyright © 1978 by American Association for the Advancement of Science
Manufactured hexaparental mice show that adults are derived from three embyronic cells
CL Markert
and
RM Petters
Two female chimeric mice have been produced by aggregates of three genetically marked eight-cell embryos. All three embryonic genotypes are clearly expressed in the pigment pattern of the adults. These hexaparental mice together with their littermates demonstrate that, in the 64-celled blastocyst, at least three cells, and probably only three, are the source of all adult tissues.
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