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Science 6 October 1978:
Vol. 202. no. 4363, pp. 56 - 58
DOI: 10.1126/science.694518

Articles

Science, Vol 202, Issue 4363, 56-58
Copyright © 1978 by American Association for the Advancement of Science


articles

Manufactured hexaparental mice show that adults are derived from three embyronic cells

CL Markert and RM Petters

Two female chimeric mice have been produced by aggregates of three genetically marked eight-cell embryos. All three embryonic genotypes are clearly expressed in the pigment pattern of the adults. These hexaparental mice together with their littermates demonstrate that, in the 64-celled blastocyst, at least three cells, and probably only three, are the source of all adult tissues.


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