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Science 29 September 1978:
Vol. 201. no. 4362, pp. 1237 - 1239
DOI: 10.1126/science.99814
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Articles

Science, Vol 201, Issue 4362, 1237-1239
Copyright © 1978 by American Association for the Advancement of Science

articles

Vaccination of experimental monkeys against Plasmodium falciparum: a possible safe adjuvant

WA Siddiqui, DW Taylor, SC Kan, K Kramer, SM Richmond-Crum, S Kotani, T Shiba, and S Kusumoto

Owl monkeys (Aotus trivirgatus griseimembra) were effectively immunized against a human malaria parasite, Plasmodium falciparum. Two injections of antigen, primarily mature segmenters with fully developed merozoites, mixed with adjuvant (6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine and liposomes) were administered intramuscularly at a 4-week interval. Approximately 2 weeks after the second vaccination, the monkeys were challenged with the homologous strain of P. falciparum. All immunized monkeys survived the challenge. The substitution of Freund's complete adjuvant is an encouraging step toward the development of an effective and safe vaccine for human malaria.


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