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Science 22 September 1978:
Vol. 201. no. 4361, pp. 1141 - 1142
DOI: 10.1126/science.684434
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Articles

Science, Vol 201, Issue 4361, 1141-1142
Copyright © 1978 by American Association for the Advancement of Science

articles

Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin

S Mondal, DW Brankow, and C Heidelberger

Impure and pure samples of saccharin (2 milligrams per milliliter) did not produce oncogenic transformation of C3H/10T1/2, clone 8, mouse embryo fibroblasts. However, after treatment of the cells with a nontransforming initiating dose (0.1 microgram per milliliter) of 3-methylcholanthrene, continuous treatment with either sample of saccharin (100 micrograms per milliliter) led to significant transformation. It is concluded that in this system saccharin is a cocarginogen, probably functioning as a promoting agent that is 1000-fold less active than the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Enhancement of Transformed Foci and Induction of Prostaglandins in Balb/c 3T3 Cells by Palytoxin: In Vitro Model Reproduces Carcinogenic Responses in Animal Models Regarding the Inhibitory Effect of Indomethacin and Reversal of Indomethacin's Effect by Exogenous Prostaglandins.
D. Miura, M. Kobayashi, S. Kakiuchi, Y. Kasahara, and S. Kondo (2006)
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Artificial sweetener use and bladder cancer: a case-control study.
E. Wynder and S. Stellman (1980)
Science 207, 1214-1216
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Genetic effects of impure and pure saccharin in yeast.
C. Moore and A Schmick (1979)
Science 205, 1007-1010
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