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Science 15 September 1978:
Vol. 201. no. 4360, pp. 1039 - 1041
DOI: 10.1126/science.684426
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Articles

Science, Vol 201, Issue 4360, 1039-1041
Copyright © 1978 by American Association for the Advancement of Science

articles

Rebound insomnia: a new clinical syndrome

A Kales, MB Scharf, and JD Kales

Rebound insomnia followed the withdrawal of three benzodiazepine hypnotic drugs, each of which had been administered in a single nightly dose for only short-term periods. The intense worsening of sleep is attributed to the short duration of the action of these drugs. A hypothesis involving benzodiazepine receptors in the brain is proposed in which there is a delay or lag in replacement of endogenous benzodiazepine-like molecules after the abrupt withdrawal of exogenous drugs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Predisposition to and Development and Persistence of Chronic Insomnia: Importance of Psychobehavioral Factors.
A. Kales and A. N. Vgontzas (1992)
Arch Intern Med 152, 1570-1572
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Sleep Disorders.
M. Z. Wincor (1990)
Journal of Pharmacy Practice 3, 221-232
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Alprazolam in Panic Disorder and Agoraphobia: Results From a Multicenter Trial: III. Discontinuation Effects.
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Arch Gen Psychiatry 45, 429-436
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Sleep Disorders: Insomnia, Sleepwalking, Night Terrors, Nightmares, and Enuresis.
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Ann Intern Med 106, 582-592
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Management of Insomnia in Hospitalized Patients.
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Ann Intern Med 100, 398-404
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Early morning insomnia with rapidly eliminated benzodiazepines.
A Kales, C. Soldatos, E. Bixler, and J. Kales (1983)
Science 220, 95-97
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Rebound insomnia.
K. Hartse, T Roth, P. Piccione, and F. Zorick (1980)
Science 208, 423-424
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Rebound Insomnia.
A. KALES, M. B. SCHARF, J. D. KALES, and C. R. SOLDATOS (1980)
Science 208, 424
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Rebound Insomnia: A Potential Hazard Following Withdrawal of Certain Benzodiazepines.
A. Kales, M. B. Scharf, J. D. Kales, and C. R. Soldatos (1979)
JAMA 241, 1692-1695
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