Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 8 September 1978:
Vol. 201. no. 4359, pp. 913 - 916
DOI: 10.1126/science.567374

Articles

Science, Vol 201, Issue 4359, 913-916
Copyright © 1978 by American Association for the Advancement of Science


articles

Formation of mutagens in beef and beef extract during cooking

B Commoner, AJ Vithayathil, P Dolara, S Nair, P Madyastha, and GC Cuca

Mutagens, distinguishable from benzo[a]pyrene and from mutagenic amino acid and protein pyrolysis products, are formed when ground beef is cooked in a home hamburger cooking appliance or when beef stock is concentrated, by boiling, to a paste known commercially as beef extract. "Well-done" hamburgers contain about 0.14 part per million of the mutagens, and beef bouillon cubes which contain beef extract about 0.1 part per million. Since such mutagens may be potentially carcionogenic and are formed during ordinary cooking procedures, their occurrence raises questions about possible risks to human health.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The initiation of breast and prostate cancer.
P. L. Grover and F. L. Martin (2002)
Carcinogenesis 23, 1095-1102
   Abstract »    Full Text »    PDF »
Modulation of mutagenic activity in meat samples after deep-frying in vegetable oils.
C. Perez, A. Lopez de Cerain, and J. Bello (2002)
Mutagenesis 17, 63-66
   Abstract »    Full Text »    PDF »
Food-Derived Heterocyclic Amine Mutagens: Variable Metabolism and Significance to Humans.
N. J. Gooderham, S. Murray, A. M. Lynch, M. Yadollahi-Farsani, K. Zhao, A. R. Boobis, and D. S. Davies (2001)
Drug Metab. Dispos. 29, 529-534
   Abstract »    Full Text »
Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA-/- mice.
J.C. Klein, R.B. Beems, P.E. Zwart, M. Hamzink, G. Zomer, H.v. Steeg, and C.F.v. Kreijl (2001)
Carcinogenesis 22, 619-626
   Abstract »    Full Text »    PDF »
Characterization of mutations induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the colon of gpt delta transgenic mouse: novel G:C deletions beside runs of identical bases.
K.-i. Masumura, K. Matsui, M. Yamada, M. Horiguchi, K. Ishida, M. Watanabe, K. Wakabayashi, and T. Nohmi (2000)
Carcinogenesis 21, 2049-2056
   Abstract »    Full Text »    PDF »
The Food-derived Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Activates S-Phase Checkpoint and Apoptosis, and Induces Gene Mutation in Human Lymphoblastoid TK6 Cells.
H. Zhu, A. R. Boobis, and N. J Gooderham (2000)
Cancer Res. 60, 1283-1289
   Abstract »    Full Text »
DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis.
H. A.J. Schut and E. G. Snyderwine (1999)
Carcinogenesis 20, 353-368
   Abstract »    Full Text »    PDF »
Basis of Cellular Autonomy in the Subsceptibility to Carcinogenesis.
J. Russo (1983)
Toxicol Pathol 11, 149-166
   Abstract »    PDF »
Carcinogenicity in mice of mutagenic compounds from a tryptophan pyrolyzate.
N Matsukura, T Kawachi, K Morino, H Ohgaki, T Sugimura, and S Takayama (1981)
Science 213, 346-347
   Abstract »    PDF »
Identifying environmental chemicals causing mutations and cancer.
B. Ames (1979)
Science 204, 587-593
   Abstract »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)