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Science 1 September 1978:
Vol. 201. no. 4358, pp. 821 - 824
DOI: 10.1126/science.210501
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Articles

Science, Vol 201, Issue 4358, 821-824
Copyright © 1978 by American Association for the Advancement of Science

articles

Generation of new mouse sarcoma viruses in cell culture

UR Rapp and C Todaro

Endogenous nontumor-producing type C viruses from C3H mice were used to generate rapid, solid tumor-inducing variants in cell culture. The new mouse sarcoma viruses induce undifferentiated sarcomas with a short latency period upon inoculation into newborn NIH Swiss mice. Transforming viruses appear only transiently, at a time when the virus-infected cells show morphologic alterations; both before and after this time, transforming viruses cannot be detected. These results show that variants of endogenous type C virus which contain transforming genes (oncogenes) can arise during spread of the endogenous virus in fibroblast lines in vitro as well as in susceptible tissues in vivo.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Endogenous Virogenes and Oncogenes in Rat-cell Transformation: A New Model System.
S. Rasheed (1980)
Cold Spring Harb Symp Quant Biol 44, 779-786
   Abstract »    PDF »
Recombination in the Avian Oncoviruses as a Model for the Generation of Defective Transforming Viruses.
R. N. Eisenman, M. Linial, M. Groudine, R. Shaikh, S. Brown, and P. E. Neiman (1980)
Cold Spring Harb Symp Quant Biol 44, 1235-1247
   Abstract »    PDF »
Evolution of Oncogenic Mouse Type-C Viruses in Cell Culture.
U. R. Rapp and G. J. Todaro (1980)
Cold Spring Harb Symp Quant Biol 44, 1289-1295
   Abstract »    PDF »


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