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Science 1 September 1978:
Vol. 201. no. 4358, pp. 819 - 821
DOI: 10.1126/science.210500
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Articles

Science, Vol 201, Issue 4358, 819-821
Copyright © 1978 by American Association for the Advancement of Science

articles

Trisodium phosphonoformate, a new antiviral compound

E Helgstrand, B Eriksson, NG Johansson, B Lannero, A Larsson, A Misiorny, JO Noren, B Sjoberg, K Stenberg, G Stening, S Stridh, and B Oberg

Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Evaluation of (1R,2R)-1-(5'-methylfur-3'-yl)propane-1,2,3-triol, a sphydrofuran derivative isolated from a Streptomyces species, as an anti-herpesvirus drug.
K. Hayashi, K. Kawahara, C. Nakai, U. Sankawa, H. Seto, and T. Hayashi (2000)
J. Antimicrob. Chemother. 46, 181-189
   Abstract »    Full Text »    PDF »
Prevention of Foscarnet Nephrotoxicity.
G. Deray, C. Katlama, and E. Dohin (1990)
Ann Intern Med 113, 332
   Abstract »    PDF »
Acyclovir Topical Therapy of Cutaneous Herpes Simplex Virus Infection in Guinea Pigs.
N.-H. Park, D. Pavan-Langston, S. L. McLean, and J. H. Lass (1980)
Arch Dermatol 116, 672-675
   Abstract »    PDF »
Inhibition of Adenylyl and Guanylyl Cyclase Isoforms by the Antiviral Drug Foscarnet.
O. Kudlacek, T. Mitterauer, C. Nanoff, M. Hohenegger, W.-J. Tang, M. Freissmuth, and C. Kleuss (2001)
J. Biol. Chem. 276, 3010-3016
   Abstract »    Full Text »    PDF »


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