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Science 18 August 1978:
Vol. 201. no. 4356, pp. 628 - 630
DOI: 10.1126/science.27864
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Articles

Science, Vol 201, Issue 4356, 628-630
Copyright © 1978 by American Association for the Advancement of Science

articles

Lymphocyte ecto-5'-nucleotidase deficiency in agammaglobulinemia

NL Edwards, DB Magilavy, JT Cassidy, and IH Fox

Fresh peripheral blood lymphocytes from eight patients with congenital agammaglobulinemia demonstrate reduced ecto-5'-nucleotidase activity when compared to the mean activity of normal subjects and patients with other forms of immunoglobulin deficiency. A specific defect of ecto-5'-nucleotidase is further suggested by normal values for lymphocyte ecto-adenosinetriphosphatase and ecto-nonspecific phosphatase. The data provide evidence for an enzyme deficiency in this X-linked, B lymphocyte deficiency syndrome.


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