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Science 4 August 1978:
Vol. 201. no. 4354, pp. 463 - 465
DOI: 10.1126/science.663668
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Articles

Science, Vol 201, Issue 4354, 463-465
Copyright © 1978 by American Association for the Advancement of Science

articles

Enkephalin-like material elevated in ventricular cerebrospinal fluid of pain patients after analgetic focal stimulation

H Akil, DE Richardson, J Hughes, and JD Barchas

Enkephalin-like activity has been measured in the ventricular cerebrospinal fluid of patients with intractable pain. Electrical stimulation of periventricular brain sites resulted in significant decrease in persistent pain in these subjects. This analgesia, which was blocked by naloxone in 80% of the cases, was accompanied by a significant rise in ventricular enkephalin-like activity, as measured by two different methods. The results present evidence of in vivo release of enkephalin-like material in humans and suggest that stimulation analgesia may be partially due to this release.


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