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Science 14 July 1978:
Vol. 201. no. 4351, pp. 157 - 159
DOI: 10.1126/science.663644
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Articles

Science, Vol 201, Issue 4351, 157-159
Copyright © 1978 by American Association for the Advancement of Science

articles

Microcirculation of the spleen: and open or closed circulation?

LT Chen

By injecting plastic microspheres of a specific size (3 to 4 micrometers) into the circulation and following their movement and distribution in the spleen, it was revealed how blood travels from the arterial capillaries to the venous sinuses. This method demonstrated that both open and closed circulation exist in the spleen and that about 90 percent of the blood takes the open route of circulation in the normal unanesthetized rabbit.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleen.
I. Safeukui, J.-M. Correas, V. Brousse, D. Hirt, G. Deplaine, S. Mule, M. Lesurtel, N. Goasguen, A. Sauvanet, A. Couvelard, et al. (2008)
Blood 112, 2520-2528
   Abstract »    Full Text »    PDF »
Ex vivo perfusion of human spleens maintains clearing and processing functions.
P. A. Buffet, G. Milon, V. Brousse, J.-M. Correas, B. Dousset, A. Couvelard, R. Kianmanesh, O. Farges, A. Sauvanet, F. Paye, et al. (2006)
Blood 107, 3745-3752
   Abstract »    Full Text »    PDF »


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